Adipocyte metabolism of the chemotherapy daunorubicin
نویسندگان
چکیده
منابع مشابه
Comparative mammalian metabolism of adriamycin and daunorubicin.
Both Adriamycin and daunorubicin undergo carbonyl reduction and glycosidic cleavage. We have investigated kinetic parameters of these reactions with several mam malian species including humans. Adriamycin and daunorubicin showed similar K values for reduction in all organs studied except those from rabbits. Both rabbit liver and kidney have a much lower K for Adriamycin reduction. In contrast t...
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mic enzyme that converts daunorubicm to a principal metabolite, daunorubicino!, in the presence of NADPH. This enzyme, found in mammalian tissues and studied in rat tissue preparations and normal human blood components, is also present in human leukemic myeloblasts. The enzymes from both normal and leukemic leukocytes require NADPH for activity, have similar kinetics and substrate saturation ch...
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ژورنال
عنوان ژورنال: Oncoscience
سال: 2018
ISSN: 2331-4737
DOI: 10.18632/oncoscience.428